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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MDH1 All Species: 53.64
Human Site: T226 Identified Species: 84.29
UniProt: P40925 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40925 NP_005908.1 334 36426 T226 L K G E F V T T V Q Q R G A A
Chimpanzee Pan troglodytes XP_001163596 334 36422 T226 L K G E F V T T V Q Q R G A A
Rhesus Macaque Macaca mulatta XP_001084973 344 37589 T236 L K G E F V T T V Q Q R G A A
Dog Lupus familis XP_531844 334 36408 T226 L K G E F I T T V Q Q R G A A
Cat Felis silvestris
Mouse Mus musculus P14152 334 36493 T226 L K G E F I T T V Q Q R G A A
Rat Rattus norvegicus O88989 334 36465 T226 L K G E F I T T V Q Q R G A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511259 334 36411 T226 L K G D F I S T V Q Q R G A A
Chicken Gallus gallus Q5ZME2 334 36525 T226 L K G D F I L T V Q Q R G A A
Frog Xenopus laevis Q6PAB3 334 36407 T226 L K G G F I T T V Q Q R G A A
Zebra Danio Brachydanio rerio NP_956263 333 36201 T226 L K G E F I S T V Q Q R G A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609394 337 36040 T226 L Q G S F V E T V Q K R G A A
Honey Bee Apis mellifera XP_394487 333 36140 T226 L N T T F V E T I Q K R G A A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796283 335 36178 T226 L N G E F I K T V Q V R G A S
Poplar Tree Populus trichocarpa
Maize Zea mays Q08062 332 35571 T226 W L N G E F I T T V Q Q R G A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93819 332 35552 S226 W L D G E F I S T V Q Q R G A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.2 95.2 N.A. 96.4 97 N.A. 91.6 90.4 86.8 78.7 N.A. 65.8 63.4 N.A. 68.3
Protein Similarity: 100 100 96.8 98.1 N.A. 99.4 99.6 N.A. 97.5 96.7 94 89.8 N.A. 77.4 77.2 N.A. 82
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 80 80 86.6 86.6 N.A. 73.3 60 N.A. 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 93.3 93.3 100 N.A. 86.6 73.3 N.A. 80
Percent
Protein Identity: N.A. 61 N.A. 61.6 N.A. N.A.
Protein Similarity: N.A. 73.9 N.A. 75.4 N.A. N.A.
P-Site Identity: N.A. 20 N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. 26.6 N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 87 94 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 14 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 54 14 0 14 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 87 14 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 80 20 0 0 0 0 0 0 0 0 87 14 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 54 14 0 7 0 0 0 0 0 0 % I
% Lys: 0 67 0 0 0 0 7 0 0 0 14 0 0 0 0 % K
% Leu: 87 14 0 0 0 0 7 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 14 7 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 7 0 0 0 0 0 0 0 87 80 14 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 87 14 0 0 % R
% Ser: 0 0 0 7 0 0 14 7 0 0 0 0 0 0 7 % S
% Thr: 0 0 7 7 0 0 47 94 14 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 34 0 0 80 14 7 0 0 0 0 % V
% Trp: 14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _